In his 1904 Nobel lecture, Ivan Pavlov described the chronic esophageal fistula preparation with which he had made many fundamental discoveries concerning canine digestion. In a particularly intriguing experiment, Pavlov observed that fasted dogs ate voraciously and continually while ingested food was removed through the fistula, becoming satiated only when gastric chyme was placed in the duodenum. This observation led to the concept of postgastric satiety mechanisms and, after the discovery of intestinal hormones, provided the basis for studying intestinal hormones as satiety-inducing agents. Many years later, Serially et al. (1967) demonstrated that enterogastrone, a gut extract undoubtedly rich in cholecystokinin (CCK), inhibited feeding by fasted mice. Since that time there have been numerous reports concerning the possible role of CCK-related peptides peripherally administered as a putative satiety factor with a variety of functions other than its well-known classical roles, i.e., its effect on gallbladder contractions and release of pancreatic enzymes.
KeywordsCortical Gray Matter Decrease Food Intake Intestinal Hormone Cholecystokinin octapeptIde Gastric Chyme
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