Corticotrophin-Releasing Hormone

Effects on Stress-Related Behavior in Rats
  • Jack E. Sherman
  • Ned H. Kalin
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


For over 25 years, investigators searched for the elusive hypothalamic hormone corticotrophin-releasing factor, hypothesized to stimulate the pituitary release of ACTH. Finally, in 1981, Vale et al. (1981) identified a 41-amino-acid peptide that potently and specifically promoted the release of ACTH from the pituitary corti-cotroph. Further work demonstrated that this peptide met the criteria established for a releasing hormone. Like other hypothalamic releasing hormones, corticotrophin-releasing hormone (CRH) and its receptors were found to have extrahypoth-alamic brain distribution (Olschowka et al., 1982; Schipper et al., 1983; Swanson et al., 1983). From results of initial studies, it was hypothesized that CRH systems play an integrative role in an organism’s response to stress.


Antinociceptive Effect Test Interval Pain Inhibition Stainless Steel Guide Cannula Constant White Noise 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jack E. Sherman
    • 1
  • Ned H. Kalin
    • 1
  1. 1.Department of PsychiatryUniversity of Wisconsin-Madison, and Psychiatry Service, William S. Middleton Memorial Veterans HospitalMadisonUSA

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