An Endogenous Peptide Ligand for the PCP/σ-Opiod Receptor

  • Patricia C. Contreras
  • Debora A. Dimaggio
  • Thomas L. O’Donohue
  • Rémi Quirion
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Opioid receptors comprise a heterogeneous group that can be divided into at least four biochemically and topographically distinct subtypes, designated (μ, κ, σ, and δ. Martin et al. (1976) proposed the existence of μ-, κ-, and α-opioid receptors based on observed differences in pharmacological profiles of drugs seen with variably selective opioid agonists and antagonists. Other groups have provided evidence for the 8 subtype (Hughes et al., 1975).


Opioid Receptor Opioid Peptide Stereotyped Behavior Endogenous Ligand Opiate Receptor 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Patricia C. Contreras
    • 1
    • 2
  • Debora A. Dimaggio
    • 3
  • Thomas L. O’Donohue
    • 3
  • Rémi Quirion
    • 4
    • 5
  1. 1.Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and StrokeNational Institutes of HealthBethesdaUSA
  2. 2.Department of MedicineHoward UniversityUSA
  3. 3.Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and StrokeNational Institutes of HealthBethesdaUSA
  4. 4.Douglas Hospital Research CentreMcGill UniversityVerdunCanada
  5. 5.Department of Psychiatry, Faculty of MedicineMcGill UniversityVerdunCanada

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