Kinins IV pp 577-583 | Cite as

Activation by Bradykinin and Vasoactive Intestinal Peptide of Adenylate Cyclase from Immunologically Sensitized Lung Membranes

  • Alison L. Gadd
  • Kanti Bhoola
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 198A)


Bradykinin receptors on normal lung membranes seem to be coupled to adenylate cyclase. Stimulation of the enzyme from sensitized lung membranes by adrenaline and vasoactive intestinal peptide was markedly reduced, whereas the ability of bradykinin and histamine to activate the sensitized adenylate cyclase was unaffected. Additional experiments are necessary in order to delineate the precise molecular events associated with activation of each of the two presently known bradykinin receptor types.


Adenylate Cyclase Vasoactive Intestinal Peptide Sodium Fluoride Guanosine Triphosphate Kinin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J. Stoner, V. C. Maganiello, and M. Vaughan, Effect of bradykinin and indomethacin on cyclic GMP and cyclic AMP in lung slices, Proc. Nat. Acad. Sci. USA, 70: 3830–3833 (1973).PubMedCrossRefGoogle Scholar
  2. 2.
    E. K. Frandsen, G. A. Krishna, and S. I. Said, Vasoactive intestinal polypeptide promotes cyclic 3f5f-monophosphate accumulation in guinea-pig trachea, Br. J. Pharmac., 62: 367–369 (1978).CrossRefGoogle Scholar
  3. 3.
    K. Ishizaka, Cellular events in the IgE antibody response, Advan. Immunol., 23: 1–75 (1976).CrossRefGoogle Scholar
  4. 4.
    P. Andersson, Antigen-induced bronchial anaphylaxis in actively sensitized guinea-pigs, Allergy, 35: 65–71 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    N. Watanabe and Z. Ovary, Antigen and antibody detection by in vivo methods: A re-evaluation of passive cutaneous anaphylactic reactions, J. Immun. Methods, 14: 381–390 (1977).CrossRefGoogle Scholar
  6. 6.
    B. L. Brown, J. D. M. Albano, R. P. Ekins, A. M. Sgherzi, and W. Tampion, A simple and sensitive saturation assay method for the measurement of adenosine 3f,5f-cyclic monophosphate, Biochem. J., 121: 561–562 (1971).PubMedGoogle Scholar
  7. 7.
    K. D. Bhoola, A. L. Gadd, and J. Maguire, Does immunological sensitization alter the activity of lung adenylate cyclase, Br. J. Pharmac., 80: 605P (1983).Google Scholar
  8. 8.
    M. Rodbell, The role of hormone receptors and GTP-regulatory proteins in membrane transduction, Nature, 284: 17–22 (1980).PubMedCrossRefGoogle Scholar
  9. 9.
    D. Regoli, Kinins, receptors, antagonists, in: flKinins-84(1984).Google Scholar
  10. 10.
    J. M. Stewart and R. J. Vavrek, Bradykinin competitive antagonists for classical kinin systems, in: MKinins-84,n (1984).Google Scholar
  11. 11.
    A. W. Cuthbert, P. V. Haluska, H. S. Margolius, and J. A. Spayne, Mediators of the secretory response to kinins, Br. J. Pharmac., 82: 597–607 (1984).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Alison L. Gadd
    • 1
  • Kanti Bhoola
    • 1
  1. 1.Department of Pharmacology, Medical SchoolUniversity of BristolBristolEngland

Personalised recommendations