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Kinins IV pp 559-562 | Cite as

Effects of Kinins on the Isolated Perfused Rat Kidney and Evidence for the Presence of Renal B1 Receptors

  • Jorge A. Guimarães
  • Maria Aparecida R. Vieira
  • Elizabeth Eich
  • Thomas Maack
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 198A)

Summary

The kinins, particularly lysyl-bradykinin (LBK), have a bimodal effect on the vasculature of isolated rat kidney. The vasorelaxant but not the vasoconstrictor effect of LBK seems to be mediated by prostaglandins. The vasoconstrictor action of LBK can be blocked by (L-Leu)8-des-Arg9-BK indicating that the rat kidney vasculature has B1 kinin-receptor which mediates the effects of kinins and/or their C-terminal metabolites.

Keywords

Renal Vascular Resistance Renal Vasculature Constrictor Effect Bimodal Effect Additional Positive Charge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jorge A. Guimarães
    • 1
    • 2
  • Maria Aparecida R. Vieira
    • 1
    • 2
  • Elizabeth Eich
    • 1
    • 2
  • Thomas Maack
    • 1
    • 2
  1. 1.Department of Biochemistry-ICBUFRJRio de JaneiroBrazil
  2. 2.Department of PhysiologyCornell University Medical CollegeNew YorkUSA

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