Effects of Kinins on the Isolated Perfused Rat Kidney and Evidence for the Presence of Renal B1 Receptors
The kinins, particularly lysyl-bradykinin (LBK), have a bimodal effect on the vasculature of isolated rat kidney. The vasorelaxant but not the vasoconstrictor effect of LBK seems to be mediated by prostaglandins. The vasoconstrictor action of LBK can be blocked by (L-Leu)8-des-Arg9-BK indicating that the rat kidney vasculature has B1 kinin-receptor which mediates the effects of kinins and/or their C-terminal metabolites.
KeywordsRenal Vascular Resistance Renal Vasculature Constrictor Effect Bimodal Effect Additional Positive Charge
Unable to display preview. Download preview PDF.
- 5.G. A. Higgs, R. J. Flower, and J. R. Vane, A new approach to anti inflammatory drugs, Biochem. Pharmacology, 28: 1959–1961, (1979).Google Scholar
- 8.E. G. Erdos, and H. Y. T. Yang, in: Handbook of Experimental Pharmacology, Vol. 26, E. G. Erdos (ed.), Berlin: Spring-Verlag, pp. 289–323, (1970).Google Scholar
- 9.K. B. Alves, C. M. W. Brandi, J. C. Souza-Pinto, and J. A. Guimaraes, Kinin-converting aminopeptidase from human urine: further purification and characterization through kinetic and inhibitory studies, Int. J. Biochemistry, (in press).Google Scholar
- 10.J. P. Curtin, and L. A. Arbeit, The effect of bradykinin on the renal blood flow of the rat, Abstract IXth, International Congress of Nephrology, 447A, (1984).Google Scholar