Role of Kininase II (ACE; E.C.18.104.22.168) in the Regulation of Renin Secretion
The activities of most proteolytic enzymes in plasma are checked by inhibitors of great versatility and capacity. In contrast, the activity of plasma renin is mainly regulated by the rate of its release from the cells of its origin. Renin is synthesized by a dozen or more cell species, yet only certain cells of the juxtaglomerular (jg) apparatus and chorionic cells secrete the active enzyme into extracellular fluids. All other renin- producing cells are also the site of angiotensin I and II (AI and AII) formation, and it is the latter which is secreted1. Inactive renin, also described as prorenin, is secreted by non-renal sources as well2. Its contribution to changes in concentrations of active renin is not certain.
KeywordsPlasma Renin Renin Secretion Plasma Renin Concentration Conscious Rabbit Calcium Channel Blocker Verapamil
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