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Kinins IV pp 367-373 | Cite as

Metabolism of Bradykinin in Isolated Perfused Rat Kidney Measurement of Kininase Activity in Perfusate and Urine

  • Tohru Ogihara
  • Therese Dupin
  • Haruyuki Nakane
  • Yoko Nakane
  • Takao Saruta
  • Jiro Misumi
  • Jöel Mènard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 198A)

Summary

The effect of bradykinin and kininase on renal function and the metabolism of bradykinin in the kidney were examined in isolated perfused rat kidney. In this experimental system, exogenous bradykinin did not affect the water and electrolyte handling by the kidney. Most of bradykinin and kininase in urine were derived from kidney but not from circulating medium. Kininase II may not have a major role in bradykinin destruction by the kidney.

Keywords

Perfuse Kidney Perfusate Sample Control Perfusion Constant Perfusion Pressure Electrolyte Handling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Tohru Ogihara
    • 1
  • Therese Dupin
    • 4
  • Haruyuki Nakane
    • 2
  • Yoko Nakane
    • 2
  • Takao Saruta
    • 3
  • Jiro Misumi
    • 4
  • Jöel Mènard
    • 4
  1. 1.Department of Internal MedicineHiratsuka City HospitalKanagawaJapan
  2. 2.Department of Internal MedicineUrawa City HospitalSaitamaJapan
  3. 3.Department of Internal MedicineKeio University School of MedicineTokyoJapan
  4. 4.Inserm U36ParisFrance

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