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Kinins IV pp 361-365 | Cite as

Endogenous Kallikrein Inhibitor in Rat Kidney Cortex-Effect of Glucocorticoid Administration

  • Kodo Ito
  • Kenichi Yamada
  • Setsuko Yoshida
  • Keiji Hasunuma
  • Yasushi Tamura
  • Sho Yoshida
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 198A)

Summary

Kallikrein inhibiting proteins with two different molecular weight (6-8 × 104, 8-9 × 104 respectively) were observed in adrenalectomized rat kidney cortical soluble fraction. The larger one was observed in the kidneys of the adrenalectomized rats only when they had received chronic administration of excess amount of dexamethasone, and its kallikrein inhibitory activity was not lost with treatment with trypsin. This protein appears to be induced by chronic administration of glucocorticoid and might participate in the process of glucocorticoid regulating renal kallikrein kinin system.

Keywords

Urinary Trypsin Inhibitor Urinary Kallikrein Kallikrein Inhibitor Kallikrein Activity Urinary Kallikrein Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Kodo Ito
    • 1
  • Kenichi Yamada
    • 1
  • Setsuko Yoshida
    • 1
  • Keiji Hasunuma
    • 1
  • Yasushi Tamura
    • 1
  • Sho Yoshida
    • 1
  1. 1.The Second Department of Internal MedicineChiba University School of MedicineChiba 280Japan

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