Kinins IV pp 347-354 | Cite as

Release of Tissue Kallikrein from the Isolated Perfused Kidney

  • Namir Lâuar
  • Kanti Bhoola
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 198A)


Experiments were designed to determine the action of regulatory peptides and potassium on the secretion of tissue kallikrein by the isolated perfused rat kidney. Such experiments indicated that in spite of the directly evoked release of kallikrein by arginine-vasopressin (AVP, ADH), oxytocin and potassium from isolated renal cortical slices, the secretion and clearance of active and total tissue kallikrein by the isolated kidney was primarily sensitive to changes in the perfusion pressure.


Perfusion Pressure Tissue Kallikrein ArtifiCial Lung Perfuse Kidney Urinary Kallikrein 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Namir Lâuar
    • 1
  • Kanti Bhoola
    • 1
  1. 1.Department of Pharmacology, Medical SchoolUniversity of BristolBristolEngland

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