Summary
At least three species of tissue kaliikrein-like antigens are present in human seminal plasma which differ in their molecular masses and enzymatic activities. At least one of these species is a genuine tissue kallikrein as judged by the criteria of molecular mass, immunoreactivity, inhibition by aprotinin and non-inhibition by soybean trypsin inhibitor, and the ability to release kallidin from kininogen. The prostatic gland was identified as the origin of the seminal fluid tissue kallikrein first by indirect studies and then by demonstrating the presence of immunoreactive tissue kallikrein both in prostatic tissue and secretion.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Johnson, A.R.: Effects of kinins on organ systems. 1%: Handbook of Exp. Pharmacol., Vol. 25 Suppl., Ed. by E.G. Erdos. Springer- Verlag pp. 357–399 (1979).
Schill, W.-B.: Kinin-releasing pancreatic proteinase kallikrein. In: Treatment of Male Infertility, ed. by J. Bain, W.-B, Schill and L. Schwarzstein. Springer-Verlag pp. 125–142 (1982).
Palm, S., Schill, W.-B. Wallner, O., Prinzen, R. and Fritz, H.: Occurrence of components of the kallikrein-kinin system in human genital tract secretions and their possible function in stimulation of sperm motility and migration. In: Kinins. Pharmacodynamics and Biological Roles, ed. by F. Sicuteri, N. Back and G.L. Haberland. Plenum Press pp. 271–279 (1976).
Fink, E., Seifert, J., Geiger, R. and Guttel, C.: Studies on the physiological function of glandular kallikrein by radioimmunoassay. In: Current Concepts in Kinin Research, ed. by G.L. Haberland and U. Hamberg. Pergamon Press pp. 111–119 (1979).
Mann, K., Goring, W., Lipp, W., Keipert, B., Karl, H.J., Geiger, R., Fink, E.: Radioimmunoassay of human urinary kallikrein. J. Clin. Chem. Clin. Biochem. 18: 395–401 (1980).
Fink, E., and Güttel, C.: Development of a radioimmunoassay for pig pancreatic kallikrein. J. Clin. Chem. Clin. Biochem. 16: 381–385 (1978).
Shimamoto, K., Ando, T., Tanaka, S., Nakahashi, Y., Nishitani, T., Hosoda, S., Ishida, H., and Iimura, O.: An improved method for the determination of human blood kinin levels by sensitive kinin radio¬immunoassay. Endocrinol. Japon. 29: 487–494, (1982).
Fink, E. and Schill, W.-B.: Tissue kallikrein in human seminal plasma. In: Kinins III, ed. by H. Fritz, N. Back, G. Dietze and G.L. Haberland. Plenum Press pp. 1175–1180 (1983).
Fink, E. and Schill, W.-B.: Studies on tissue kallikrein in human seminal plasma. In: Kininogenases. Kallikrein. Vol. 6, ed. by G.L. Haberland, J.W. Rohen, H. Fritz, and P. Huber. Schattauer Verlag pp. 147–154 (1983).
Fink, E., Schill, W.-B. and Fiedler, F.: Tissue kallikrein in human seminal fluid. In: Protides of the Biological Fluids. XXXIInd Colloquium, ed. by H. Peeters. Pergamon Press, in press.
Marin-Grez, M. and Carretero, O.A.: A method for measurement of urinary kallikrein. J. Appl. Physiol. 32: 428–431 (1972).
Fiedler, F., Hinz, H. and Lottspeich, F.: Individual reaction steps in the release of kallidin from kininogen by tissue kallikrein. (This volume).
Bhoola, K.D., May May Yi, R., Morley, J. and Schachter, M.: Release of kinin by an enzyme in the accessory sex glands of the guinea- pig. J. Physiol. 163: 269–280 (1962).
Suominen, J.J.O. and Niemi, M.: Influence of human seminal proteases on vascular permeability. Nature New Biol. 232: 90–91 (1971).
Suominen, J.J.O.: Properties of kallikrein-like enzyme and plasminogen activators of human seminal plasma. In: Conference Proc. VI Mott Center Symposium. Techniques of Human Andrology. Ed. by E.S.E. Hafez. Elsevier, Amsterdam, abstract 20 (1976).
Geiger, R. and Clausnitzer, B.: Isolation of enzymatically active tissue kallikrein from human seminal plasma by immunoaffinity chromatography. Hoppe-Seyler’s Z. Physiol. Chem. 362: 1279–1283 (1981).
Schill, W.-B., Krassnigg, F., Müller-Esterl, W. and Fink, E.: Quantitative determination of different proteins in normal and pathological semen. In: Protides of the Biological Fluids, ed. by H. Peeters. Pergamon Press, in press.
Lazure, C., Leduc, R., Seidah, N.G., Chretien, M., Dube, J.Y., Chapdelaine, P., Frenette, G., Paquin, R. and Tremblay, R.R.: The major androgen-dependent protease in dog prostate belongs to the kallikrein family: confirmation by partial amino acid seqencing. FEBS Letters 175: 1–7 (1984).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Fink, E., Schill, WB., Fiedler, F., Shimamoto, K., Krassnigg, F., Frick, J. (1986). The Tissue Kallikrein-Kinin System in Human Seminal Plasma — Biochemical and Functional Aspects. In: Greenbaum, L.M., Margolius, H.S. (eds) Kinins IV. Advances in Experimental Medicine and Biology, vol 198A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5143-6_40
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5143-6_40
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5145-0
Online ISBN: 978-1-4684-5143-6
eBook Packages: Springer Book Archive