Kinins IV pp 273-277 | Cite as

Regulation of Parotid Kallikrein Secretion-Role of the Alpha2- and Beta-Adrenergic System

  • Arnold Röckel
  • Adolf Preissler
  • August Heidland
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 198A)


The effects of pharmacologically induced alterations of alpha1, alpha2 and beta-adrenergic system on kallikrein secretion - measured as amidolytic activity - in rat parotid gland were tested in vivo. Beta and alpha1/2-adrenergic stimulation (Orciprenaline, alpha-methylnorepinephrine) caused a comparably significant increase of parotid kallikrein secretion. Alpha2-receptor blockade (yohimbine) but not the alpha1-antagonist prazosin, partly abolished the effect of alpha-methylnorepinephrine. The effects of the alpha1-adreno-receptor agonist norfenephrine on kallikrein secretion were significantly lower compared to alpha1/2-adreno-receptor-stimulation.

Parotid kallikrein secretion is preferentially dependent on beta- and alpha2-adrenergic activity.


Submandibular Gland Mean Arterial Blood Pressure Salivary Flow Enzyme Secretion Parotid Saliva 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Arnold Röckel
    • 1
  • Adolf Preissler
    • 1
  • August Heidland
    • 1
  1. 1.Deutsche Klinik Für DiagnostikWiesbaden Med. Univ. Hosp.WürzburgGermany

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