Abstract
One approach which can be used to discover the function(s) of the kallikrein-kinin system is to make the assumption that tissue kallikrein can generate lysyl bradykinin (LBK, kallidin) in tissues, where it then acts as local hormone. If this be true then it follows that novel effects of kinin may be discovered in tissues where kallikrein is especially localized. Consideration of these effects may then allow some conclusions to be drawn about the roles of the kallikrein-kinin system in either physiological or pathological states.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
R. G. Geller, H. S. Margolius, J. J. Pisano, and H. R. Keiser, Effects of mineralocorticoids, altered sodium intake and adrenalectomy on urinary kallikrein in rats, Circulation Res., 31: 857–861 (1972).
H. S. Margolius, D. Horwitz, J. J. Pisano, and H. R. Keiser, Urinary kallikrein excretion in hypertensive man. Relationships to sodium uptake and sodium-retaining steroids, Circulation Res., 35: 820–825 (1974).
G. G. Orce, G. A. Castillo, and H. S. Margolius, Inhibition of short circuit current in toad urinary bladder by inhibitors of glandular kallikrein, Am. J. Physiol., 239: F459–F465 (1980).
A. Zimmerman, R. Geiger, and H. Kortmann, Similarity between a kinino- genase (kallikrein) from human large intestine and human urinary kallikrein, Hoppe-Seyler’s Z. Physiol. Chem., 360: 1767–1773 (1979).
A. W. Cuthbert, and H. S. Margolius, Kinin effects on electrolyte transport in rat colon, J. Physiol., 319: 45P (1981).
A. W. Cuthbert and H. S. Margolius, Kinins stimulate net chloride secretion by rat colon, Brit. J. Pharmacol., 75: 587–598 (1982).
A. W. Cuthbert, P. V. Halushka, H. S. Margolius, and J. A. Spayne, Role of calcium ions in kinin-induced chloride secretion, Brit. J. Pharmacol., 82: 587–595 (1984).
A. W. Cuthbert, P. V. Halushka, H. S. Margolius, and J. A. Spayne, Mediators of the secretory response to kinins, Brit. J. Pharmacol., 82: 597–607 (1984).
A. W. Cuthbert, P. V. Halushka, D. Kessel, H. S. Margolius, and W. C. Wise, Kinin effects on chloride secretion do not require eicosanoid synthesis, Brit. J. Pharmacol., 83: 549–554 (1984).
D. Manning, S. H. Snyder, J. F. Kachur, R. J. Miller, and M. Field, Bradykinin receptor-mediated chloride secretion in intestinal function, Nature, 299: 256–259 (1982).
J. Hardcastle, P. T. Hardcastle, R. J. Flower, and P. A. Sandford, The effect of bradykinin on the electrical activity of rat jejunum, Experientia, 34: 617–618 (1978).
H. H. Ussing and K. Zerahn, Active-transport of sodium as the source of electric current in the short-circuited isolated frog skin, Acta Physiol. Scand., 23: 110–127 (1951).
R. A. Frizzell, M. Field, and S. G. Schultz, Sodium-coupled chloride transport by epithelial tissue, Am. J. Physiol., 236: F1–F8 (1979).
M. Donowitz, in the control of active intestinal Na and CI transport: Involvement in neurohumoral action, Am. J. Physiol., 245: G165–G177 (1983).
A. W. Cuthbert, Calcium dependent chloride secretion in rat colon epithelium, J. Physiol., In press (1984).
J. J. Pisano, Observations on the kallikrein-kinin system in the kidney, in: “Kinins III. Adv. Exp. Med. & Biol.,” 156B:929–938 (1983).
T. B. Orstavik, K. Nustad, P. Brandtzaeg, and J. V. Pierce, Cellular origin of urinary kallikreins, J. Histochem. Cytochem., 24: 1037–1039 (1976).
D. Proud, M. Perkins, J. V. Pierce, K. N. Yates, P. F. Highet, P. L. Herring, M. M. Mark, R. Bahn, F. Carone, and J. J. Pisano, Characterization and localization of human renal kininogen, J. Biol. Chem., 256: 10634–10639 (1981).
D. Proud, M. A. Kepper, and J. J. Pisano, Distribution of immunoreactive kallikrein along the rat nephron, Am. J. Physiol., 244: F510–F515 (1983).
K. Tomita and J. J. Pisano, Binding of bradykinin in isolated nephron segments of the rabbit, Am. J. Physiol., 246: F732–F737 (1984).
K. Tomita, H. Endou, and F. Sakai, Localization of kallikrein-like activity along a single nephron in rabbits, Pflugers. Arch., 389: 91–95 (1981).
J. S. Handler, F. M. Perkins, and J. P. Johnson, Studies of renal cell function using cell culture techniques, Am. J. Physiol., 238: F1–F9 (1980).
F. M. Perkins and J. S. Handler, Transport properties of toad kidney epithelia in culture, Am. J. Physiol., 241: C154–C159 (1981).
F. C. Grenier, T. E. Rollins, and W. L. Smith, Kinin-induced prosta glandin synthesis by renal papillary collecting tubule cells in culture, Am. J. Physiol., 241: F94–F104 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Cuthbert, A.W., MacVinish, L.J. (1986). Transporting Epithelia as Targets for Kinin Effects. In: Greenbaum, L.M., Margolius, H.S. (eds) Kinins IV. Advances in Experimental Medicine and Biology, vol 198A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5143-6_28
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5143-6_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5145-0
Online ISBN: 978-1-4684-5143-6
eBook Packages: Springer Book Archive