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Kinins IV pp 85-89 | Cite as

Amino Acid Sequence of the Light Chain of Human High Molecular Mass Kininogen

  • Josef Kellermann
  • Friedrich Lottspeich
  • Agnes Henschen
  • Werner Müller-Esterl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 198A)

Summary

The light chain of human high molecular mass kininogen consists of 255 amino acid residues. The half-cystine residue which forms the single disulfide bridge to the heavy chain is located in position 225. The light chain contains 9 O-glycosidically linked carbohydrate side chains. A comparison of the human high molecular mass kininogen light chain with the bovine high molecular mass kininogen light chain reveals a pronounced homology. However, in position 88 of the human sequence an insertion of 22 amino acid residues was found. This insertion and an amino acid exchange in position 131 may explain the different behaviour of human and bovine high molecular mass kininogen during plasma kallikrein digestion.

Keywords

Light Chain Clotting Activity Cyanogen Bromide Amino Acid Exchange Hydrogen Fluoride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Josef Kellermann
    • 1
    • 2
  • Friedrich Lottspeich
    • 1
    • 2
  • Agnes Henschen
    • 1
    • 2
  • Werner Müller-Esterl
    • 1
    • 2
  1. 1.Max-Planck-Institut für BiochemieMartinsriedDeutschland
  2. 2.Abteilung für Klinische Chemie und BiochemieUniversität MünchenMünchenDeutschland

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