Advertisement

Aggressive and Protective Immunological Reactions of the Pregnant Mother to the Conceptus

  • Guy André Voisin
Part of the Reproductive Biology book series (RBIO)

Abstract

In order to clearly analyze the immune processes involved in gestation, five established points must be stated and accepted from the beginning.

Keywords

Suppressor Cell Recurrent Spontaneous Abortion Pregnant Mother Immune Agent Rejection Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Antczak, D.F. and Allen, W.R., 1984, Invasive trophoblast in the genus equus. Ann. Immunol. (Inst. Pasteur), 135D:325.CrossRefGoogle Scholar
  2. Beer, A.E., 1984, How did your mother not reject you?, Ann. Immunol. (Inst.Pasteur), 135D: 315.CrossRefGoogle Scholar
  3. Bell, S.C. and Billington, W.D., 1980, Major anti-paternal alloantibody induced by murine pregnancy is non-complement-fixing IgGl, Nature (Lond), 288: 387.CrossRefGoogle Scholar
  4. Bobé, P., Doric, M., Kinsky, R.G. and Voisin, G.A., 1984, Modulation of mouse anti-SRBC antibody response by placental extracts, Cell. Immunol., 89: 355.PubMedCrossRefGoogle Scholar
  5. Chaouat, G., Chaffaux, S., Duchet-Suchaux, M. and Voisin, G.A., 1980, Immunoactive products of mouse placenta. I — Immuno-suppressive effects of crude and water soluble extracts, 3. Reprod. Immunol., 2:127.CrossRefGoogle Scholar
  6. Chaouat, G., Kiger, N., Kolb, J.P., Stanislawski, M. and Wegmann, T.G., 1985, Immunological consequences of vaccination against abortion in mice, J. Immunol., 134: 1594.PubMedGoogle Scholar
  7. Chaouat, G., Kiger, N. and Wegmann, T.G., 1983, Vaccination against spontaneous abortion in mice., J. Reprod. Immunol, 5: 389.PubMedCrossRefGoogle Scholar
  8. Chaouat, G., Kolb, J.P. and Riviere, M., 1984, Role of the placental interface and of trophoblast/maternal tissue interactions in the survival of the murine foetal allograft, Ann. Immunol. (Inst. Pasteur.), 135D: 302.Google Scholar
  9. Chaouat, G., Monnot, P., Hoffmann, M. and Voisin, G.A., 1982, Regulatory T cells in pregnancy. VI — Evidence for T-cell mediated suppression of CTL generation towards paternal alloantigens, Cell. Immunol., 68: 322.PubMedCrossRefGoogle Scholar
  10. Chaouat, G. and Voisin, G.A., 1979, Regulatory T cell subpopulations in pregnancy. I — Evidence for suppressive activity of the early phase of MLR, J. Immunol. 122: 1383.PubMedGoogle Scholar
  11. Chaouat, G. and Voisin, G.A., 1981a, Regulatory T cells in pregnancy. IV — Genetic characteristics and mode of action of early MLR suppressive T cells populations, J. Immunol., 127: 1335.PubMedGoogle Scholar
  12. Chaouat, G. and Voisin, G.A., 1981b, Regulatory T cells in pregnancy. V — Allopregnancy induced T cell suppressor factor is H-2 restricted and bears Ia determinants, Cell. Immunol., 62:186.PubMedCrossRefGoogle Scholar
  13. Chaouat, G., Voisin, G.A., Escalier, D. and Robert, P., 1979, Facilitation reaction (enhancing antibodies and suppressor cells) and rejection reaction (sensitized cells) from the mother to the paternal antigens of the conceptus, Clin. exp. Immunol., 35:13.PubMedGoogle Scholar
  14. Chateaureynaud-Duprat, P., Badet, M.-T. and Voisin, G.A., 1979, Antagonistic immune reactions (rejection and facilitation) to the embryo in the urodele amphibian salamandra salamandra Lin, J. Reprod. Immunol., 1: 47.CrossRefGoogle Scholar
  15. Clark, D.A., 1984, Local suppressor cells and the success or failure of the “foetal allograft”, Ann. Immunol. (Inst. Pasteur), 135D: 321.CrossRefGoogle Scholar
  16. Clark, D.A., 1985, Materno-fetal relations. Review, Immunol. Lett., 9: 239.PubMedCrossRefGoogle Scholar
  17. Clark, D.A., Chaput, A., Walker, C. and Rosenthal, K.L., 1985, Active suppression of host-vs-graft disease in pregnant mice. VII — Soluble suppressor activity obtained from decidua of allopregnant mice blocks the response to IL2, J. Immunol., 134: 1659.PubMedGoogle Scholar
  18. Davies, M., 1985, An ELISA for the detection of maternal anti-trophoblast antibodies in human pregnancy, J. Immunol. Meth., 77: 109.CrossRefGoogle Scholar
  19. Duc, H.T., Massé, A., Bobé, P., Kinsky, R.G. and Voisin, G.A., 1985, Deviation of humoral and cellular alloimmune reactions by placental extracts, J. Reprod. Immunol., 7: 27.PubMedCrossRefGoogle Scholar
  20. Faulk, W.P., 1984, Humoral keystones in the gestational voussoir, Ann. Immunol. (Inst. Pasteur), 135D: 319.CrossRefGoogle Scholar
  21. Faulk, W.P. and McIntyre, I.A., 1983, Immunologic studies of human trophoblast: markers, subsets and functions, Immunol. Lett., 75:139.Google Scholar
  22. Gill, T.J. III, 1984, Speculations on the transplantation biology of the maternalfetal interface, Ann. Immunol (Inst. Pasteur), 135D: 307.CrossRefGoogle Scholar
  23. Hull, S., 1984, Anti-fetal antibody response in syngeneic pregnancy. B. Sc. thesis, University of Bristol. (Cited in W.D. Billington, Ann. Immunol. (Inst. Pasteur), 1984, 135D: 331).Google Scholar
  24. McLntyre, I.A. and Faulk, W.P., 1983, Recurrent spontaneous abortion in human pregnancy: results of immunogenetical, cellular and humoral studies, Amer. J. Reprod. Immunol., 4:165.Google Scholar
  25. Mowbray, J.F., Gibbings, C.R., Sidgwick, A.J., Ruszkiewicz, M. and Beard, R.W., 1983, Effects of transfusion in women with recurrent spontaneous abortion, Transplant. Proc., 15: 896.Google Scholar
  26. Rocklin, R.E., Kitzmiller, J.L. and Garvoy, M.R., 1982, Maternal fetal relation. II — Further characterization of an immunologic blocking factor that develops during pregnancy, Clin. Immunol. Immunopath., 22:305.CrossRefGoogle Scholar
  27. Rocklin, R.E., Kitzmiller, J.L. and Kaye, M.D., 1979, Immunobiology of the maternal fetal relationship, Annu. Rev. Med., 30: 375.PubMedCrossRefGoogle Scholar
  28. Singh, B., Raghupathy, R., Anderson, D. and Wegmann, T.G., 1983, The placenta as an immunological barrier between mother and fetus, in “Immunology of Reproduction”, T.G. Wegmann and T.J. Gill, eds, Oxford University Press., London.Google Scholar
  29. Smith, G., 1983, In vitro susceptibility of murine placental trophoblast to cytotoxic effector cells, J. Reprod. Immunol., 5: 39.PubMedCrossRefGoogle Scholar
  30. Voisin, G.A., 1971, Immunological facilitation, a broadening of the concept of enhancement phenomenon, Progr. Allergy, 15: 328.CrossRefGoogle Scholar
  31. Voisin, G.A., 1980, Role of antibody classes in the regulatory facilitation reaction. in “Regulation of the immune response by antibodies against the immunogen”, Immunol. Rev., 49: 3.PubMedCrossRefGoogle Scholar
  32. Voisin, G.A., 1983a, Immunological interventions of the placenta in maternal immunological tolerance to the foetus, in “Immunology of Reproduction”, T.G. Wegmann and T.J. Gill III, eds, Oxford University Press, London.Google Scholar
  33. Voisin, G.A., 1983b, Enhancing antibodies and suppressor cells in pregnancy: role of the placentation, in “Reproductive Immunology”, S. Isojima and W.D. Billington, eds, Elsevier Sciences Publ., Amsterdam.Google Scholar
  34. Voisin, G.A. and Chaouat, G., 1974, Demonstration, nature and properties of antibodies fixed on maternal placenta and directed against paternal antigens, J. Reprod. Fertil, Suppl. 21: 89.Google Scholar
  35. Voisin, J., Kinsky, R.G. and Voisin, G.A., 1983, Immunodepressive action of placental extracts on allo-immunisation as tested by graft-versus-host reactions (GVHR) in non H-2 histoincompatible strains. In “5th Int. Congress of Immunology”, Kyoto, abstract 310–09.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Guy André Voisin
    • 1
  1. 1.Centre d’Immuno-Pathologie et d’Immunologie Expérimentale (INSERM) U 23, UA 289 CNRS, C 12 Ass.C.Bernard; Hôp.St-AntoineParis Cédex 12France

Personalised recommendations