Effects of Active Immunization with Follicle Stimulating Hormone (FSH) on Spermatogenesis in the Adult Crab Eating Monkey- Evaluation for Male Contraception
It is well known that both follicle stimulating hormone (FSH) and luteinizing hormone (LH) are required for normal testicular function. The role of FSH in spermatogenesis has been the subject of intense investigation in the last few years. In the rat, FSH is required during the first wave of spermatogenesis, but not in the adult (Madhwa Raj and Dym, 1976; Dym et al., 1977; Madhwa Raj et al., 1980). However, in the adult bonnet (Sheeia Rani et al., 1978; Murty et al., 1979, 1980) and the rhesus (Wickings and Nieschlag, 1980) monkeys, FSH has been shown to play an important role in spermatogenesis. In the studies mentioned above, both passive and active immunization procedures have been employed. We first reported the effects of active immunization with FSH and FSH-β subunit in the crab eating monkey (Madhwa Raj et al., 1980). Considerable interest has been evinced in evaluatig methods that might selectively suppress spermatogenesis leaving androgen production and androgen dependent parameters intact, for purpose of achieving male contraception. Thus it is important to examine the role of FSH in spermatogenesis and effects of selective withdrawal of this hormone on fertility and sexual behaviour in the primate model. We report here the chronic effects of neutralizing FSH (by active immunization with ovine FSH or ovine FSH-β subunit) in the male crab eating monkey, Macaca fasicularis.
KeywordsluteiniZing Hormone Follicle Stimulate Hormone Sertoli Cell Sperm Count Bonnet Monkey
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