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Immunization Against FSH as a Method of Male Contraception

  • Jeffrey Spieler
Part of the Reproductive Biology book series (RBIO)

Abstract

In May 1985 I had the opportunity of participating in an International Workshop on Male Contraception in Geneva, Switzerland sponsored by the Program for Applied Research on Fertility Regulation (PARFR), Northwestern University. PARFR invited Professor Eberhard Nieschlag of the Max Planck Clinical Research Unit for Reproductive Medicine, Munster, Federal Republic of Germany, to present a paper on immunization against FSH as a male method of fertility regulation. Professor Nieschlag informed PARFR that the results of his work in this area were discouraging and that his group had abandoned the approach. Not dissuaded by negative results, PARFR reinvited Professor Nieschlag to present a paper on the reasons for abandoning immunization against FSH as an approach to male fertility regulation.(1) Because Professor Nieschlag was unable to attend the Fogerty Symposium I would like to summarize some of his findings for you.

Keywords

Cynomolgus Monkey Sperm Count Testicular Volume Fertility Regulation Testosterone Enanthate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    E., Nieschlag, Reasons for abandoning immunization against FSH as an approach to male fertility regulation, in: “Male Contraception: Advances and Future Prospects,” G. I. Zatuchni, A. Goldsmith, J. J. Sciarra and J. M. Spieler, eds., Harper and Row, Philadelphia (1986, in preparation).Google Scholar
  2. 2.
    E. J., Wickings, Usadel, K. H. Dathe, G. and Nieschlag, E., The role of follicle stimulating hormone in testicular function of the mature rhesus Monkey, Acta Endocr. 95: 117 (1980).PubMedGoogle Scholar
  3. 3.
    B. R., Srinath, Wickings E.J., Witting, C. and Nieschlag, E., Active immunization with follicle stimulating hormone for fertility control: A 4 ½-year study in male rhesus monkeys, Fertil. Steril. 40: 110 (1983).PubMedGoogle Scholar
  4. 4.
    H.G.M., Raj, Murty, G.S.R.C., Sairam, M.R. and Talbert, L.M., Control of spermatogenesis in primates: Effects of active immunization against FSH in the monkey, Int. J. Androl., Suppl. 5:27 (1982).Google Scholar
  5. 5.
    G.S.R.C., Murty, Rani, C.S.S., Moudgal, N.R. and Prasad, M.R.N., Effect of passive immunization with specific antiserum to FSH on the spermatogenesis process and fertility of adult male bonnet monkeys (Macaca radiata), J. Reprod. Fertil., Suppl. 26:147 (1979)Google Scholar
  6. 6.
    N.R. Moudgal, — This SymposiumGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jeffrey Spieler
    • 1
  1. 1.Research DivisionOffice of Population Agency for International DevelopmentUSA

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