Advertisement

Organization of Mutant Genes in Mouse t-Haplotypes

  • Dorothea Bennett
Part of the Stadler Genetics Symposia Series book series (SGSS)

Abstract

Embryonic lethal mutations at the “T-locus” in the mouse (Mus musculus) were first identified more that 50 years ago (Dobrovolskaia-Zawaclskaia, 1927) and quickly recognized by L.C. Dunn and his colleagues as providing valuable material for studying the genetics of development (Chesley and Dunn, 1936). Studies of that locus have occupied generations of scientists since that time, and provided significant insights into both development and the organization of genes that regulate it. This paper will attempt to trace the evolution of our understanding of the structure of the “T-locus” and to speculate on what it may teach us in the future when its secrets finally succumb to the techniques of molecular biology.

Keywords

Transmission Ratio Lethal Mutation Wild Mouse Recombinant Chromosome Lethal Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Artzt, K., McCormick, P., and Bennett, D., 1982, Gene mapping within the T/t complex of the mouse. I. t-Lethal genes are nonallelic, Cell, 28:463.PubMedCrossRefGoogle Scholar
  2. Artzt, K., Shin, H-S., and Bennett, D., 1982, Gene mapping within the T/t complex of the mouse. II. Anomalous position of the H-2 complex in t-haplotypes, Cell, 29:969.PubMedCrossRefGoogle Scholar
  3. Artzt, K., Shin, H-S., Bennett, D., and DiMeo-Talento, A., 1985, Analysis of MHC haplotypes of t-chromosomes reveals the majority of diversity is generated by recombination, J. Exp. Med., in press.Google Scholar
  4. Bennett, D., 1975, The T-locus of the mouse: a review, Cell, 6:441.CrossRefGoogle Scholar
  5. Bennett, D., 1978, Population genetics of T/t complex mutations, in: “Origins of Inbred Mice,” H.C. Morse, ed., Academic Press, New York, pp. 615–632.CrossRefGoogle Scholar
  6. Bennett, D., and Dunn, L.C., 1971, Transmission ratio distorting genes on chromosome IX and their interactions, in: Proc. Symp. “Immunogenetics of the H-2 System,” Liblice-Prague, pp. 90–187.Google Scholar
  7. Bennett, D., Alton, A.K., and Artzt, K., 1983, Genetic analysis of transmission ratio distortion by t-haplotypes in the mouse, Genet. Res., Camb., 41:29.CrossRefGoogle Scholar
  8. Brickell, P.M., Latchman, D.S., Murphy, D., Willison, K., and Rigby, P.W.J., 1983, Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogens is in the mouse, Nature, 306:756.PubMedCrossRefGoogle Scholar
  9. Chesley, P., and Dunn, L.C., 1936, The inheritance of taillessness (anury) in the house mouse, Genetics, 21:525.PubMedGoogle Scholar
  10. Davis, M.M., Kim, S.K., and Hood, L., 1980, Immunoglobulin class switching: developmentally regulated DNA rearrangements during differentiation, Cell, 22:1.PubMedCrossRefGoogle Scholar
  11. Dobrovolskaia-Zawadskaia, N., 1927, Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l’existence d’un caractere (facteur hereditaire) non-viable, C.R. Soc. de Biol., 97:114.Google Scholar
  12. Dunn, L.C., 1937, A third lethal in the T (Brachy) series in the house mouse, Proc. Natl. Acad. Sci., USA, 23:474.PubMedCrossRefGoogle Scholar
  13. Goldbard, S.B., Verbanac, K.M., and Warner, C.M., 1982, Role of the H-2 complex in preimplantation mouse embryo development, Biol. Reprod., 26:591.PubMedCrossRefGoogle Scholar
  14. Hammerberg, C., and Klein, J., 1975, Evidence for postmeiotic effect of t factors causing segregation distortion in mouse, Nature, 253:137.PubMedCrossRefGoogle Scholar
  15. Herskowitz, I., 1983, Cellular differentiation, cell lineages, and transposable genetic cassettes in yeast, in: “Current Topics in Developmental Biology,” 18, A.A. Moscona and A. Monroy, eds., Academic Press, New York, pp. 1–14.Google Scholar
  16. Klein, J., Sipos, P., and Figueroa, F., 1984, Polymorphism of t-complex genes in European wild mice, Genet. Res., Camb., 44:39.CrossRefGoogle Scholar
  17. Lyon, M.F., 1984, Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus, Cell, 37:621.PubMedCrossRefGoogle Scholar
  18. Lyon, M.F., and Meredith, R., 1964a, Investigations of the nature of t-alleles in the mouse. I. Genetic analysis of a series of mutants derived from a lethal allele, Heredity, 19:301.PubMedCrossRefGoogle Scholar
  19. Lyon, M.F., and Meredith, R., 1964b, Investigations of the nature of t-alleles in the mouse. II. Genetic analysis of an unusual mutant allele and its derivatives, Heredity, 19:313.PubMedCrossRefGoogle Scholar
  20. Lyon, M.F., and Meredith, R., 1964c, Investigations of the nature of t-alleles in the mouse. III. Short tests of some further mutant alleles, Heredity, 19:327.PubMedCrossRefGoogle Scholar
  21. Murphy, D., Brickell, P.M., Latchman, D.S., Willison, K., and Rigby, P.W.J., 1983, Transcripts regulated during normal embryonic development and oncogenic transformation share a repetitive element, Cell, 35:856.CrossRefGoogle Scholar
  22. Rohme, D., Fox, H., Herrmann, B., Frischauf, A-M., Edstome, J-E., Mains, P., Silver, L.M., and Lehrach, H., 1984, Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes, Cell, 36:783.PubMedCrossRefGoogle Scholar
  23. Sage, R.D., 1981, Wild mice, in: “The Mouse in Biomedical Research,” vol. 1, H.L. Foster, J.D. Small, and J.G. Fox, eds., Academic Press, New York, pp. 39–90.Google Scholar
  24. Seitz, A., and Bennett, D., 1985, Transmission distortion of t-haplotypes is due to interactions between meiotic partners, not intrinsic superiority of t-bearing sperm, Nature, in press.Google Scholar
  25. Shin, H-S., Bennett, D., and Artzt, K., 1984, Gene mapping within the T/t complex of the mouse. IV. The inverted MHC is intermingled with several t-lethal genes, Cell, 39: 573.PubMedCrossRefGoogle Scholar
  26. Shin, H-S., McCormick, P., Artzt, K., and Bennett, D., 1983, Cis-trans test shows a functional relationship between non-allelic lethal mutations in the T/t complex, Cell, 33:925.PubMedCrossRefGoogle Scholar
  27. Shin, H-S., Stavnezer, J., Artzt, K., and Bennett, D., 1982, The genetic structure and origin of t-haplotypes of mice, analyzed with H-2 cDNA probes, Cell, 29:969.PubMedCrossRefGoogle Scholar
  28. Silver, L.M., 1981, A structural gene (Tcp-1) within the mouse t complex is separable from effects on tail length and lethality but may be associated with effects on spermatogenesis, Genet. Res., Camb., 38:115.CrossRefGoogle Scholar
  29. Silver, L.M., 1982, Genomic analysis of the H-2 complex region associated with mouse t haplotypes, Cell, 29:961.PubMedCrossRefGoogle Scholar
  30. Silver, L.M., and Artzt, K., 1981, Recombination suppression of mouse t-haplotypes is due to chromatin mismatching, Nature, 290:68.PubMedCrossRefGoogle Scholar
  31. Silver, L.M., White, M., and Artzt, K., 1980, Evidence for unequal crossing over within the mouse T/t complex, Proc. Natl. Acad. Sei., USA, 77:6077.CrossRefGoogle Scholar
  32. Silver, L.M., Uman, J., Danska, J., and Garreis, J.I., 1983, A diversified set of testicular cell proteins specified by genes within the mouse t complex, Cell, 35:35.PubMedCrossRefGoogle Scholar
  33. Styrna, J., and Klein, J., 1981, Evidence for two regions in the mouse t complex controlling transmission ratios, Genet. Res., Camb., 38:315.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Dorothea Bennett
    • 1
  1. 1.Laboratory of Developmental GeneticsSloan-Kettering Institute for Cancer ResearchNew YorkUSA

Personalised recommendations