Organization of Mutant Genes in Mouse t-Haplotypes
Embryonic lethal mutations at the “T-locus” in the mouse (Mus musculus) were first identified more that 50 years ago (Dobrovolskaia-Zawaclskaia, 1927) and quickly recognized by L.C. Dunn and his colleagues as providing valuable material for studying the genetics of development (Chesley and Dunn, 1936). Studies of that locus have occupied generations of scientists since that time, and provided significant insights into both development and the organization of genes that regulate it. This paper will attempt to trace the evolution of our understanding of the structure of the “T-locus” and to speculate on what it may teach us in the future when its secrets finally succumb to the techniques of molecular biology.
KeywordsTransmission Ratio Lethal Mutation Wild Mouse Recombinant Chromosome Lethal Gene
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