Intraspecies Genomic Variation
Genomic variation is obviously the primary source of evolutionary change, however at present two major issues stand in the way of understanding its full significance: first, we know little yet about the kinds and amounts of variation; second, we need to identify the minor fraction of the variation which affects genes and their regulatory systems. Nevertheless genomic variation is fascinating, both because so little is known and because the data we do have shows unexpectedly large variation. In addition silent or non-coding variation is very much larger than amino acid replacement variation in coding regions of the DNA of the three species for which comparisons can now be made, indicating that selection retards the change of most amino acids in most proteins.
KeywordsRestriction Fragment Length Polymorphism Replacement Substitution Genome Size Variation Silent Substitution Beta Globin
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