Cell Lineage and Cell Interactions in the Determination of Developmental Cell Fates
A central problem of developmental biology is to understand the sequence of cellular and molecular events which transforms a fertilized egg into a mature organism composed of a precise spatial array of distinct cell types. A significant consideration in addressing this problem is the fact that each of the many cells in the mature organism is descended from the egg via a lengthy sequence of progenitor cell divisions. In order to reduce the number of variables associated with the problem, many embryologists have concentrated on invertebrates such as nematodes, annelids, molluscs and tunicates in which the sequence of embryonic cell divisions is highly stereotyped. Because of this regularity it is possible to portray the development of the entire organism by the genealogical relationship between the composite cells, and to identify individual cells on the basis of their lineage (Zur Strassen, 1896; Conklin, 1905; Schleip, 1936).
KeywordsBlast Cell Pattern Element Genealogical Relationship Developmental Fate Determine Cell Fate
Unable to display preview. Download preview PDF.
- Anderson, D.T., 1973, “Embryology and phylogeny in Annelids and Arthropods,” Pergamon Press, Oxford.Google Scholar
- Conklin, E.G., 1905, The organization and cell lineage of the ascidian egg, J. Acad. Nat. Sci. Philadelphia, 13:1–119.Google Scholar
- Gimlich, R.L., and Braun, J., 1985, Improved fluorescent compounds for tracing cell lineage, Dev. Biol., in press.Google Scholar
- Kramer, A.P., and Weisblat, D.A., 1985, Developmental neural kinship groups in the leech, J. Neurosci., in press.Google Scholar
- Schleip, W., 1936, Ontogenie der Hirudineen, in: “Klassen und Ordnungen des Tierreichs,” Part 2, H.G. Bronn, ed., Akad. Verlagsgesellschaft, Leipzig, pp. 1–121.Google Scholar
- Shankland, M., 1986, Positional interaction of embryonic founder cells during the development of the leech nervous system, Current Topics in Dev. Biol., in press.Google Scholar
- Stuart, D.K., Glover, J.C., Blair, S.S., and Weisblat, D.A., 1983, Development of leech serotonin neurons examined with serotonin antibody, cell lineage tracer and cell killing, Soc. Neurosci. Abstr., 9:605.Google Scholar
- Whitman, C.O., 1878, The embryology of Clepsine. Quart. J. Micro. Sci. 18:215–315.Google Scholar