Mechanism of Organ Specificity in Nitrosamine Carcinogenesis
The nitrosamines exhibit remarkable species and tissue specificity in their carcinogenic action (Shank and Magee, 1981). The biological basis of this specificity, however, is poorly understood. A primary target for many nitrosamines, particularly unsymmetrical dialkylnitrosamines, is the rat esophagus. These nitrosamines induce high incidences of basal and squamous cell tumours, independent of the route of administration.
KeywordsPartial Hepatectomy Orotic Acid Carcinogenic Activity Squamous Cell Tumour Esophageal Necrosis
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