Mechanism of Organ Specificity in Nitrosamine Carcinogenesis

  • Michael C. Archer
  • K. Charles Silinskas
  • Peter F. Zucker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


The nitrosamines exhibit remarkable species and tissue specificity in their carcinogenic action (Shank and Magee, 1981). The biological basis of this specificity, however, is poorly understood. A primary target for many nitrosamines, particularly unsymmetrical dialkylnitrosamines, is the rat esophagus. These nitrosamines induce high incidences of basal and squamous cell tumours, independent of the route of administration.


Partial Hepatectomy Orotic Acid Carcinogenic Activity Squamous Cell Tumour Esophageal Necrosis 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Michael C. Archer
  • K. Charles Silinskas
  • Peter F. Zucker

There are no affiliations available

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