Enzyme Catalysed Cleavage of the N-N Bond of N-Nitrosamines

  • K. E. Appel
  • M. Bauszus
  • I. Roots
  • C. S. Rühl
  • A. G. Hildebrandt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


The bioactivation pathway of N-nitrosamines is very well understood and has been investigated. The rate limiting step is the cytochrome P-450 dependent hydroxylation on the 𝛼-carbon (1, 2). Very little is known however about possible inactivation pathways.


Nitric Oxide Liver Microsome Nitrite Formation Piperonyl Butoxide Oxidative Demethylation 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • K. E. Appel
    • 1
  • M. Bauszus
    • 1
  • I. Roots
    • 2
  • C. S. Rühl
    • 1
  • A. G. Hildebrandt
    • 1
  1. 1.Max von Pettenkofer InstituteGerman Health OfficeBerlin 33Germany
  2. 2.Klinikum SteglitzBerlin 41Germany

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