Age and Sex Differences in Constitutive Forms of Cytochrome P-450 of Rat Liver Microsomes

  • John B. Schenkman
  • Leonard V. Favreau
  • Ingela Jansson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


Knowledge of the cytochrome P-450 monooxygenase system has come a long way since the reports of’its hemoprotein nature.1,2Initial studies revealed some drug and chemical-treated animals respond to challenge by such agents with an increase in the hepatic microsomal content of cytochrome P-450. It wasn’t long, however, before it was realized that the cytochrome P-450 increase was the result of an induction of different forms of cytochrome P-450.3,4


Liver Microsome Microsomal Protein Constitutive Form Liver Microsomal Cytochrome Hydroxylapatite Column 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • John B. Schenkman
    • 1
  • Leonard V. Favreau
    • 1
  • Ingela Jansson
    • 1
  1. 1.Department of PharmacologyUniversity of Connecticut Health CenterFarmingtonUSA

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