Chemistry of Metabolites of Thioureas

  • Audrey E. Miller
  • Judith J. Bischoff
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


Thiourea and some monosubstituted thioureas are toxic and tumorogenic while 1,3-diarylthioureas are not. There are strong indications that the biological activity of these compounds is due to oxidation at sulfur followed by reactions in which the sulfur moiety is separated from the rest of the molecule. That is, the metabolism of toxic thioureas, involves this loss of sulfur while nontoxic compounds are either excreted unchanged or undergo alternate metabolism.1–3 The oxidation at sulfur is probably catalyzed by FAD-containing monooxygenase (FADMO). Model studies show that this enzyme oxidizes thioureas to the S-monoxide and S,S-dioxide. The slower oxidation in solution to the corresponding trioxides does not appear to be catalyzed by FADMO. 4,5


None None Potassium Carbonate Slow Oxidation Sulfur Moiety Alternative Metabolic Pathway 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Audrey E. Miller
    • 1
  • Judith J. Bischoff
    • 1
  1. 1.Department of ChemistryUniversity of ConnecticutStorrsUSA

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