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Inhibition of Respiration in Rabbit Proximal Tubules by Bromophenols and 2-Bromohydroquinone

  • Rick G. Schnellmann
  • Lazaro J. Mandel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)

Abstract

The kidney cortex is a highly aerobic and metabolically active tissue rich in mitochondria and Na-and K-dependent adenosine triphosphatase (Na,K-ATPase) activity. The basal respiration rate of a suspension of rabbit proximal tubules utilizes 50-60 percent of the mitochondrial respiratory capacity (Harris et al., 1981). Since Na,K-ATPase-mediated ion transport consumes more metabolic energy than any other single enzymatic process within the mammalian organism, it is not surprising that rabbit proximal tubules utilize half of their basal respiration for this process (Cohen and Kamm, 1976; Harris et al., 1981). The remaining half of their basal respiration is divided between ATP generation for other processes and nonphosphorylating respiration. Using isolated mitochondria, nonphosphorylating respiration has been shown to be 5–8 percent of the basal respiration (Davis et al., 1974).

Keywords

Proximal Tubule Mitochondrial Respiration Sodium Butyrate Basal Respiration Renal Proximal Tubule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Rick G. Schnellmann
    • 1
  • Lazaro J. Mandel
    • 1
  1. 1.Department of PhysiologyDuke University Medical CenterDurhamUSA

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