Intracellular Dissipative Structures (IDS) as Ultimate Targets of Chemical Cytotoxicity

  • S. Ji
  • S. Ray
  • R. Esterline
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


The primary objective of this communication is to present a general theory of chemically induced cell injury and cell death that is based partly on experimental observations on acetaminophen hepatotoxicity (Ji et al., 1985a) and partly on a recently developed theoretical model of the living cell called the Bhopalator (Ji, 1985a, b). First, we will summarize experimental data on acetaminophen hepatotoxicity. Second, the Bhopalator model of the living cell will be described. Finally, the idea that the universal mechanistic features of all chemical cytotoxicity can be recognized only at the level of intracellular dissipative structures (IDS) will be elaborated.


Covalent Binding Dissipative Structure Pyridine Nucleotide Benzoquinone Imine Tissue Fluorescence 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • S. Ji
    • 1
  • S. Ray
    • 1
  • R. Esterline
    • 1
  1. 1.Department of Pharmacology and ToxicologyRutgers UniversityPiscatawayUSA

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