Abstract
Cyclophosphamide is a commonly used anti-tumor and immunosuppressive agent. It is also mutagenic and teratogenic in a variety of species. Studies of the embryo have demonstrated that exposure to cyclophosphamide during organogenesis results in a spectrum of malformations that include exencephaly or hydrocephaly, open eyes, cleft palate, phocomelia, adactyly, syndactyly, polydactyly and kinky tail as well as disturbances in skeletal ossification (Gibson & Becker, 1968; Mirkes, 1985). Cyclophosphamide is usually teratogenic in a narrow dose range — lower doses have no apparent effects while higher doses are highly embryolethal.
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© 1986 Plenum Press, New York
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Hales, B.F., Brissette, P. (1986). Time Course of the Effect of 4-Hydroperoxycyclophosphamide on Limb Differentiation in Vitro. In: Kocsis, J.J., Jollow, D.J., Witmer, C.M., Nelson, J.O., Snyder, R. (eds) Biological Reactive Intermediates III. Advances in Experimental Medicine and Biology, vol 197. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5134-4_80
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DOI: https://doi.org/10.1007/978-1-4684-5134-4_80
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