3-Hydroxy-Trans-7,8-Dihydro-7,8-Dihydroxy-Benzo(a)Pyrene, a Metabolite of 3-Hydroxybenzo(a)Pyrene

  • O. Ribeiro
  • C. A. Kirkby
  • P. C. Hirom
  • P. Millburn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


3-Hydroxybenzo(a)pyrene(3-OH-BP) (I) is a major metabolite of the environmental pro-carcinogen BP. It is produced in a wide variety of biological systems (1–4) and is excreted as a glucuronide in bile (5, 6). Under appropriate conditions it binds to DNA (7) but it is not carcinogenic (8) and is a poor tumour initiator (9).


Enterohepatic Circulation Hydrogen Sulphate Biliary Metabolite Pyrene Metabolite Aryl Sulphatase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • O. Ribeiro
    • 1
  • C. A. Kirkby
    • 1
  • P. C. Hirom
    • 1
  • P. Millburn
    • 1
  1. 1.Dept. of BiochemistrySt. Mary’s Hospital Medical SchoolLondonUK

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