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Deoxyguanosine Adducts Formed from Benzoquinone and Hydroquinone

  • L. Jowa
  • S. Winkle
  • G. Kalf
  • G. Witz
  • R. Snyder
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)

Abstract

The mechanism by which benzene produces bone marrow damage is not known with certainty, but it is generally accepted that the toxicity is mediated by one or more benzene metabolites. Radiolabeled metabolites of benzene administered in vivo have been shown to covalently bind to DNA in rat liver (Lutz and Schlatter, 1977) and mouse bone marrow (Gill and Ahmed, 1981). Rabbit bone marrow mitoplasts have been found to metabolize benzene to products which bind to mitochondria) DNA (Rushmore, et al., 1984). Hydrolysis of the DNA to nucleosides yielded 6–7 possible adducts to guanosine. It is hypothesized that the covalent binding of benzene metabolites to DNA may be an etiological factor in benzene-induced bone marrow depression.

Keywords

Potassium Phosphate Buffer Aplastic Anemia Covalent Binding Mouse Bone Marrow Benzene Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • L. Jowa
    • 1
  • S. Winkle
    • 2
  • G. Kalf
    • 3
  • G. Witz
    • 1
  • R. Snyder
    • 1
  1. 1.Joint Program In ToxicologyUSA
  2. 2.Department of ChemistryRutgers Univ. and UMDNJ/Rutgers Medical/SchoolPiscatawayUSA
  3. 3.Department of BiochemistryThomas Jefferson UniversityPhiladelphiaUSA

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