H-2 Modulation of Aryl Hydrocarbon Hydroxylase Induction and the Mutagenicity of Benzo(a)Pyrene after 3-Methylcholanthrene Treatment

  • B. A. Brooks
  • D. L. Wassom
  • J. G. Babish
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


Pretreatment of animals with polycyclic aromatic compounds such as 3-methylcholanthrene (MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin can alter the subsequent biotransformation of foreign compounds both quantitatively and qualitatively (Conney, 1982; Nebert et al., 1981; Lu and West, 1980). These changes in metabolism are a result of an increase (termed induction) in several drug metabolizing enzymes including cytochrome P1-450 (Negishi and Nebert, 1979), and P3-450 (Negishi and Nebert, 1979; Negishi et al., 1981). Mouse P1-450 and P3-450 are defined (Gonzalez et al., 1984) as those forms of MC-induced cytochrome P-450 having the highest turnover number for induced aryl hydrocarbon hydroxylase (AHH) and acetanilide 4-hydroxylase activity, respectively. Addition-ally, P1-450 is associated with the production of mutagenic and carcinogenic metabolites of benzo(a)pyrene (BP) as well as other polycyclic hydrocarbons (reviewed in Pelkonen and Nebert, 1982).


Major Histocompatibility Complex Congenital Adrenal Hyperplasia Congenic Strain Polycyclic Aromatic Compound Aryl Hydrocarbon Hydroxyl 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • B. A. Brooks
    • 1
  • D. L. Wassom
    • 1
  • J. G. Babish
    • 1
  1. 1.Department of Preventive MedicineNYS College of Veterinary Medicine Cornell UniversityIthacaUSA

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