Formation of a Ring-Opened Product from Benzene in a Hydroxyl Radical Generating System

  • L. Latriano
  • B. D. Goldstein
  • G. Witz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


Benzene, a ubiquitous compound in our petrochemical society, has been shown to cause hematoxicity and leukemia in both animals and humans. Current evidence strongly suggests that a metabolite(s) of benzene mediates its toxicity (Snyder et al., 1981). The closed-ring metabolites on the main path of benzene metabolism, e.g. phenol, catechol and hydroquinone, have been studied by many investigators, and though there have been many promising leads, the origin and identification of the toxic metabolite(s) remain uncertain


High Performance Liquid Chromatography Bone Marrow Cellularity Beta Scission Muconic Acid High Performance Liquid Chromatography Condition 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • L. Latriano
    • 1
  • B. D. Goldstein
    • 1
  • G. Witz
    • 1
  1. 1.Dept. of Environmental and Community MedicineUMDNJ-Rutgers Medical School Busch CampusPiscatawayUSA

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