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Flavin-Containing Monooxygenase Activity in Human Liver Microsomes

  • M. E. McManus
  • D. J. Birkett
  • W. M. Burgess
  • I. Stupans
  • J. A. Koenig
  • A. R. Boobis
  • D. S. Davies
  • P. J. Wirth
  • P. H. Grantham
  • S. S. Thorgeirsson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)

Abstract

In laboratory animals both the flavin-containing and cytochrome P450 monooxygenase enzymes have been shown to be involved in the metabolism of nitrogen and sulfur containing compounds (1). Multiple forms of both these enzymes have now been reported and the composition of these monooxygenases is known to differ greatly between animal species, among individuals of the same species, and between organs in the same species (2,3). The differential distribution of these monooxygenases has been used to explain species, individual and organ selective toxicity of drugs and chemical carcinogens (4). Clearly, characterization of the monooxygenases involved in the metabolism of nitrogen and sulfur containing compounds, and definition of the regulatory control of these processes, is essential for understanding the biological disposition of these chemicals.

Keywords

Human Liver Microsome Microsomal Protein Cytochrome P450 System Cytochrome P450 Content Cytochrome P450 Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • M. E. McManus
    • 1
  • D. J. Birkett
    • 1
  • W. M. Burgess
    • 1
  • I. Stupans
    • 1
  • J. A. Koenig
    • 1
  • A. R. Boobis
    • 2
  • D. S. Davies
    • 2
  • P. J. Wirth
    • 3
  • P. H. Grantham
    • 3
  • S. S. Thorgeirsson
    • 3
  1. 1.Department of Clinical PharmacologyFlinders UniversitySouth Australia
  2. 2.Royal Postgraduate Medical SchoolLondonUK
  3. 3.National Cancer InstituteBethesdaUSA

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