Piperonyl Butoxide Reduces Salicylate-Induced Nephrotoxicity and Covalent Binding in Male Rats

  • Marlene E. Kyle
  • James J. Kocsis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


The salicylates are among the most widely used therapeutic agents in the world. Their effectiveness in treating pain, fever and inflammation all contribute to the extensive use of these drugs. Although generally regarded as safe, a number of side effects have been associated with the administration of salicylates. In particular, the development of kidney toxicity is of concern as this damage may lead to renal failure and death (NIH Consensus Development Conference, 1984).


Blood Urea Nitrogen Covalent Binding Kidney Homogenate Analgesic Nephropathy Piperonyl Butoxide 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Marlene E. Kyle
    • 1
  • James J. Kocsis
    • 1
  1. 1.Department of PharmacologyThomas Jefferson UniversityPhiladelphiaUSA

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