Mechanism of Fasting-Induced Suppression of Acetaminophen Glucuronidation in the Rat

  • Veronica F. Price
  • Jennifer M. Schulte
  • Stephen M. Spaethe
  • David J. Jollow
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


Acetaminophen overdosage, taken either as a suicidal gesture or as an accidental poisoning, is a significant clinical entity and one that appears to be growing in incidence. Results from a recent study have shown that the percentage of total drug-related deaths associated with acetaminophen in England and Wales rose dramatically from 3.8% in 1973 to 21% in 1980; further, the number of acetaminophen-associated deaths was the highest of all drug-related deaths for the years 1978 to 1980 (1). Thus there is a need to define more clearly the reasons for differences in patient responsiveness and to develop new treatment regimens to decrease the severity of liver failure.


Blood Glucose Level Reactive Metabolite Glycogen Level Glycogen Deposition Increase Blood Glucose Level 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Veronica F. Price
    • 1
  • Jennifer M. Schulte
    • 1
  • Stephen M. Spaethe
    • 1
  • David J. Jollow
    • 1
  1. 1.Department of PharmacologyMedical University of South CarolinaCharlestonUSA

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