p-Nitrosophenetole: A Reactive Intermediate of Phenacetin that Binds to Protein

  • Jack A. Hinson
  • Joann B. Mays
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


Although phenacetin is an effective analgesic, in a small number of chronic abusers it has been proven to be toxic causing interstitial nephritis and progressive reduction in kidney size and function (1). Moreover, a signficant number of tumors of the urinary tract have been reported in the same population (2). Phenacetin also produces methemoglobinemia and hemolysis in genetically susceptible individuals (3). Because of its toxicities, and in particular its known tumorigenicity in animals and suspected carcinogenicity in human, it has been removed from the U.S. market.


Interstitial Nephritis Microsomal Protein Reactive Metabolite Analgesic Abuse Suspected Carcinogenicity 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jack A. Hinson
    • 1
  • Joann B. Mays
    • 1
  1. 1.National Center for Toxicological ResearchJeffersonUSA

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