Inhibition of RNA Synthesis in Mouse Macrophages and Lymphocytes by Benzene and Its Metabolites
Chronic exposure of laboratory animals and man to benzene leads to progressive degeneration of bone marrow resulting in aplastic anemia and leukemia (Snyder et al., 1977; Cronkite et al., 1984). The mechanism by which benzene produces myelotoxicity is unknown; substantial evidence indicates that toxicity results from its metabolism to one or more compounds (Snyder et al., 1982) which accumulate in bone marrow (Andrews et al., 1977); these have been shown to be phenol, catechol, and hydro-quinone (Rickert et al., 1979) which can further oxidize to p-benzoquinone.
KeywordsConditioned Medium Aplastic Anemia Peritoneal Exudate Cell Spleen Lymphocyte Rubber Policeman
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