Biological Reactive Intermediates of Pyrrolizidine Alkaloids

  • Donald R. Buhler
  • Bogdan Kedzierski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


The hepatotoxic and carcinogenic pyrrolizidine alkaloids (PAs) present in Senecio and a number of other plant genera are responsible for the poisoning of humans and animals in many parts of the world (Hirono, 1981; Huxtable, 1979; McLean, 1970). Fatalities or severe cases of poisoning in humans have resulted from the consumption of grain contaminated by PA containing seeds or by drinking supposedly therapeutic herbal teas that contain PAs (Hirono, 1981; Huxtable, 1980; McLean, 1970). There is also increasing evidence that the PAs are excreted in toxic form in the milk of cows and goats consuming PA containing plants such as tansy ragwort (Senecio jacobaea) (Dickinson et al., 1976; Luthy et al., 1983; Miranda et al., 1981; Deinzer et al., 1982).


High Performance Liquid Chromatography High Performance Liquid Chromatography Method Pyrrolizidine Alkaloid Microsomal Metabolism Mouse Liver Microsome 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Donald R. Buhler
    • 1
  • Bogdan Kedzierski
    • 1
  1. 1.Department of Agricultural Chemistry and Environmental Health Sciences CenterOregon State UniversityCorvallisUSA

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