Hydroxylamines and Hemolytic Anemia

  • David J. Jollow
  • Scott J. Grossman
  • James H. Harrison
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


Hemolytic anemia, the uncompensated loss of red blood cells from the circulation, has been recognized as a side effect of drugs and other chemicals for over 50 years (Muelens, 1926; Cordes, 1926). This response is commonly associated with the aminoquinoline drugs, pamaquine and primaquine (Beutler, 1959); indeed the extensive studies carried out with these drugs in the 1940’s and 50’s by Alving, Carson, Beuiler, and others still serve as the basis for most of our knowledge in the clinical sequelae of drug-induced hemolysis.


Hemolytic Anemia Hemolytic Activity Active Oxygen Species Hemolytic Effect Blood Radioactivity 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • David J. Jollow
    • 1
  • Scott J. Grossman
    • 1
  • James H. Harrison
    • 1
  1. 1.Department of PharmacologyMedical University of South CarolinaCharlestonUSA

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