Role of Parenchymal Versus Non-Parenchymal Cells on the Control of Biologically Reactive Intermediates

  • Franz Oesch
  • Mark Lafranconi
  • Hans-Ruedi Glatt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


The non-parenchymal cells (NPC) of the liver have the potential to significantly influence the formation of reactive intermediates in the liver because of their critical location along the sinusoids where they are the first cells to encounter blood borne xenobiotics. To study the possible role of the NPC in the metabolism of xenobiotics, populations of NPC and parenchymal cells (PC) were prepared from rats and various xenobiotic metabolizing enzyme activities investigated. The specific activity of every enzyme studied was 12 to 1000% higher in the PC than in the NPC populations and the pattern of activities between the 2 populations was remarkably different. The NPC also displayed a more dramatic response to Aroclor 1254 induction of enzyme activities than did the PC. Furthermore, the NPC were capable of forming biologically reactive intermediates which caused cyto- and genotoxicity. From these data we conclude that the NPC provide a distinct contribution to hepatic metabolism of xenobiotics.


Parenchymal Cell Reactive Intermediate Epoxide Hydrolase Mercapturic Acid Bacterial Mutagenicity 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Franz Oesch
    • 1
  • Mark Lafranconi
    • 1
  • Hans-Ruedi Glatt
    • 1
  1. 1.Institut für ToxikologieUniversität MainzMainzGermany

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