Active Oxygen and Toxicity
Active forms of oxygen are becoming increasingly implicated in the etiology of numerous disease states and the toxicities of various drugs and chemicals. Among the former are the initiation and promotion of tumors (Petkau, 1980) and rheumatoid arthritis (Rowley et al., 1984), while the latter includes toxicities such as that associated with anthracycline antibiotics (Goodman and Hochstein, 1977), and paraquat (Bus et al., 1974). The generation of active oxygen species during normal cellular metabolism such as prostaglandin and leukotriene biosynthesis (Kalyanaraman and Sivarajah, 1984) or by stimulated polymorphonuclear leukocytes or macrophages (Babior and Peters, 1981) is now widely recognized.
KeywordsLipid Peroxidation Xanthine Oxidase Phospholipid Liposome Normal Cellular Metabolism Ferritin Iron
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