Reactive Oxygen Species Formed in Vitro and in Cells: Role of Thiols(GSH). Model Studies with Xanthine Oxidase and Horseradish Peroxidase
Reactive oxygen species are being widely studied with respect to their biological significance. When a disturbance occurs in the delicate balance between prooxidants and antioxidants in favor of the former, there is a biological response thought to be the basis of a number of physiological and pathophysiological phenomena. This condition is being referred to as oxidative stress (see (1)).
KeywordsSinglet Oxygen Xanthine Oxidase Glutathione Disulfide Thiyl Radical Singlet Molecular Oxygen
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- 1.H. Sies, Oxidative Stress: Introductory Remarks, in: “Oxidative Stress”, H. Sies, ed., p. 1, Academic Press, Orlando (1985)Google Scholar
- 2.H. Sies and E. Cadenas, Oxidative stress: damage to intact cells and organs, Phil.Trans.R.Soc.Lond.B., in press (1985)Google Scholar
- 9.H. Wefers and H. Sies, Formation of excited species during glutathione oxidation, in:“4th International Conference on Superoxide and Superoxide Dismutase”, Rome (J. Geelen, ed.) Elsvier Science Publ. B.V., Amsterdam, in press (1985)Google Scholar
- 10.I. Yamazaki, Peroxidase, in: “Molecular mechanisms of oxygen activation”, O. Hayaishi, ed., p. 535, Academic Press, New York (1974)Google Scholar
- 13.H. Wefers, E. Riechmann and H. Sies, Excited species generation in horseradish peroxidase-catalyzed oxidation of glutathione. J.Free Radicals Biol.Med. 1, in press (1985)Google Scholar