Reactive Oxygen Species Formed in Vitro and in Cells: Role of Thiols(GSH). Model Studies with Xanthine Oxidase and Horseradish Peroxidase

  • Heribert Wefers
  • Helmut Sies
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


Reactive oxygen species are being widely studied with respect to their biological significance. When a disturbance occurs in the delicate balance between prooxidants and antioxidants in favor of the former, there is a biological response thought to be the basis of a number of physiological and pathophysiological phenomena. This condition is being referred to as oxidative stress (see (1)).


Singlet Oxygen Xanthine Oxidase Glutathione Disulfide Thiyl Radical Singlet Molecular Oxygen 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Heribert Wefers
    • 1
  • Helmut Sies
    • 1
  1. 1.Institut für Physiologische Chemie IUniversität DüsseldorfDüsseldorfWest Germany

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