Activation of Nitrosamines to Mutagens by Rat and Rabbit Nasal, Lung and Liver S-9 Homogenates

  • Alan R. Dahl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


Over 30 nitrosamines have been reported to cause cancer in the nasal cavities of laboratory animals (Dahl, 1985). A majority of the observed tumors followed systemic administration of the nitrosamine, although in a few experiments inhalation was the route of exposure. Nitrosamine-caused nasal tumors and the binding of nitrosamine-introduced radioactivity in the nasal cavity (Brittebo et al., 1981; Löfberg et al., 1982) may result from the activity of the high concentrations of xenobiotic metabolizing enzymes in the nasal cavity (Dahl et al., 1982; Bond 1983; Hadley and Dahl, 1983).


Nasal Cavity Ames Test Nasal Tissue Rabbit Tissue Experiment Inhalation 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Alan R. Dahl
    • 1
  1. 1.Lovelace Inhalation Toxicology Research InstituteAlbuquerqueUSA

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