Activation of Nitrosamines to Mutagens by Rat and Rabbit Nasal, Lung and Liver S-9 Homogenates
Over 30 nitrosamines have been reported to cause cancer in the nasal cavities of laboratory animals (Dahl, 1985). A majority of the observed tumors followed systemic administration of the nitrosamine, although in a few experiments inhalation was the route of exposure. Nitrosamine-caused nasal tumors and the binding of nitrosamine-introduced radioactivity in the nasal cavity (Brittebo et al., 1981; Löfberg et al., 1982) may result from the activity of the high concentrations of xenobiotic metabolizing enzymes in the nasal cavity (Dahl et al., 1982; Bond 1983; Hadley and Dahl, 1983).
KeywordsNasal Cavity Ames Test Nasal Tissue Rabbit Tissue Experiment Inhalation
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