Thiyl Radicals--Their Generation and Further Reactions

  • David Ross
  • Peter Moldeus
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


Amongst the functions of glutathione (GSH) is the protection of cells against reactive electrophilic species. Many xenobiotics can generate reactive substrate-derived radicals during metabolism (1) and other free radicals such as superoxide anion radical (\(O\overset{{\underset{\scriptscriptstyle\centerdot}{-}}}{\mathop{2}}\,\)) can be generated during normal cellular function (2). Thus the interaction of GSH with free radicals is of both physiological and toxicological significance. The reduction of free radicals by GSH, however, generates another radical--the glutathionyl radical (GS·), the fate of which in biological systems is poorly understood.


Oxygen Uptake Xanthine Oxidase Normal Cellular Function Thiyl Radical Toxicological Significance 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • David Ross
    • 1
  • Peter Moldeus
    • 1
  1. 1.Department of ToxicologyKarolinska InstituteStockholmSweden

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