Metabolism of Diehtylstilbestrol by Horseradish Peroxidase and Prostaglandin Synthase — Evidence for a Free Radical Intermediate
Diethylstilbestrol (DES) is carcinogenic in animals (1) and its use as an abortifacient in humans has been linked to the appearance of reproductive tract tumours in both the male and female offspring of mothers who were treated with the drug (2–4). The mechanisms underlying DES carcinogenicity are as yet unresolved but have been thought to involve the estrogenic activity of the compound (1). Recent data, however, demonstrates that hormonal activity alone is insufficient to explain the carcinogenicity of DES (5–7).
KeywordsThiyl Radical Vaginal Cancer Free Radical Intermediate Syrian Hamster Embryo DMPO Adduct
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