Toxicologic Implications of the Iron-Dependent Activation of Bleomycin A2 by Mouse Lung Microsomes
The bleomycins are a family of glycopeptide antiobiotics currently being utilized in the chemotherapy of human neoplastic diseases (1). Unlike many antineoplastic agents, bleomycin does not elicit significant myelosuppressive activity, which is advantageous not only when considering bleomycin as a single chemotherapeutic agent but also when incorporating it in multiple agent modalities. The administration of bleomycin is accompanied however by the development of dose-limiting pulmonary toxicity which can manifest as life-threatening interstitial fibrosis. Understanding the underlying chemico-biological interactions by which bleomycin initiates alterations in cellular function is important from the standpoint of developing rational chemoprotective strategies.
KeywordsPulmonary Toxicity Lung Microsome Terminal Substituent Ascorbic Acid Radical Bleomycin Hydrolase
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