The FAD-Containing Monooxygenase of Lung and Liver Tissue from Rabbit, Mouse and Pig: Species and Tissue Differences

  • Patrick J. Sabourin
  • R. E. Tynes
  • B. P. Smyser
  • E. Hodgson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


The FAD-containing monooxygenase (EC is a microsomal flavoprotein capable of oxidizing a wide range of nitrogen, sulfur and phosphorus containing compounds. These include secondary and tertiary (but not primary) aliphatic amines, arylamines, hydrazines, sulfides, thiols, thioamides and thioureas.1–6 The pig liver FAD-containing monooxygenase (FMO) has been purified and extensively characterized,7–9 however, only recently has this enzyme been studied in other species and tissues.10–14,17 It is apparent from these studies that there are species and tissue differences in the flavin-containing monooxygenase. This paper describes some of the more recent advances towards characterizing this enzyme in different species and tissues and also extends the large list of compounds which are substrates.


Mouse Liver Rabbit Liver Rabbit Lung NADPH Oxidation Primary Aliphatic Amine 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Patrick J. Sabourin
    • 1
  • R. E. Tynes
    • 2
  • B. P. Smyser
    • 2
  • E. Hodgson
    • 2
  1. 1.Lovelace Inhalation Toxicology Research InstituteAlbuquerqueUSA
  2. 2.Interdepartmental Toxicology Program North Carolina State UniversityRaleighUSA

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