Further Evidence for a Role of Isozymes of P450 in the Metabolism and Toxicity of Carbon Disulfide (CS2)

  • R. J. Rubin
  • R. Kroll
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 197)


CS2 has been shown to undergo sequential desulfuration in the liver to form CO2. Previous work by Neal and his colleagues1,2 has revealed that the initial desulfuration is catalyzed by a cytochrome P450-dependent enzyme system which results in the formation of an electrophilic sulfur atom and carbonyl sulfide (COS). They have further shown3 that the second desulfuration step is catalyzed primarily by a soluble, acetazoleamideinhibitable carbonic anhydrase which results in the formation of CO2 and hydrogen sulfide (H2S) (Figure 1).


Hydrogen Sulfide Carbon Disulfide Pretreatment Time Carbonyl Sulfide Aniline Hydroxylase 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. J. Rubin
    • 1
  • R. Kroll
    • 1
  1. 1.School of Hygiene and Public HealthThe Johns Hopkins UniversityBaltimoreUSA

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