Evidence for Sex Differences in GnRH Receptors and Mechanism of Action

  • R. Mitchell
  • S.-A. Ogier
  • M. Johnson
  • A. Cleland
  • J. Bennie
  • G. Fink
Part of the Biochemical Endocrinology book series (BIOEND)


Over recent years, a number of hypotheses have been proposed for the biochemical mechanism of action of Gonadotropin-Releasing Hormone (GnRH). Although adenosine 3′, 5′-monophosphate (cAMP) has been implicated as a second messenger in GnRH action (Borgeat et al, 1972), this has been refuted (Conn et al., 1979) and Cronin et al (1983) have shown that changes in Luteinizing Hormone (LH) secretion are not temporally coupled to changes in cAMP levels. An apparently direct effect of cAMP derivatives on GnRH receptors (Smith et al, 1982) may have contributed to some of these results.


GnRH Receptor Luteinizing Hormone Secretion Female Tissue GnRH Action cAMP Derivative 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. Mitchell
    • 1
  • S.-A. Ogier
    • 1
  • M. Johnson
    • 1
  • A. Cleland
    • 1
  • J. Bennie
    • 1
  • G. Fink
    • 1
  1. 1.MRC Brain Metabolism UnitUniversity Department of PharmacologyEdinburghUK

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