The Biosynthesis of LHRH
Many small peptides, possessing hormonal or neurotransmitter properties are synthesised as part of large precursor forms which often incorporate the sequences of more than one biologically active molecule. For example, β-preprotachykinin incorporates the sequences of both substance P and substance K (Nawa et al., 1983), and similarly oxytocin and arginine-vasopressin are synthesised within the same precursor molecule as their respective associated proteins, neurophysins I and II (Land et al., 1983). Two common features of precursor molecules which have thus far been identified are the presence of a short hydrophobic signal sequence at the N-terminus and the presence of paired basic amino acids at the boundaries of the active peptide sequences which form cleavage sites for further processing of the large molecules.
KeywordsLuteinizing Hormone Translation Product High Molecular Weight Form Hypothalamic Peptide Hypothalamic Extract
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