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Gonadotropin-Releasing Hormone: Differentiation of Structure and Function During Evolution

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Neuroendocrine Molecular Biology

Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

Gonadotropin-releasing hormone (GnRH) has been important in the short history of peptide neurobiology. The sequence of GnRH isolated from mammalian brains was established in 1971 and 1972 (Matsuo et al., 1971; Burgus et al., 1972). An identical peptide was shown to exist in human placenta (Tan and Rousseau, 1982). However, GnRH was not the first peptide to be sequenced. For example, the structures of oxytocin, vasopressin and thyroid-releasing hormone in vertebrates and eledoisin in octopus were known. But the central role of GnRH in reproduction led to extensive studies of its function, conformation and location. In the 14 years since the structure of GnRH was elucidated, over 2,000 analogues have been synthesized and tested (Struthers et al., 1985). Also it is now clear that GnRH is a member of a family of homologous peptides, has multiple functions, is located both within and out of the central nervous system and has well-studied neuro-transmitter actions.

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  1. Biology Department, University of Victoria, Victoria, B.C., Canada

    Nancy M. Sherwood

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  1. MRC Brain Metabolism Unit, Edinburgh, Scotland

    G. Fink  & A. J. Harmar  & 

  2. The International Foundation for Biochemical Endocrinology, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns

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© 1986 Plenum Press, New York

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Sherwood, N.M. (1986). Gonadotropin-Releasing Hormone: Differentiation of Structure and Function During Evolution. In: Fink, G., Harmar, A.J., McKerns, K.W. (eds) Neuroendocrine Molecular Biology. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5131-3_7

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  • DOI: https://doi.org/10.1007/978-1-4684-5131-3_7

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