The Biosynthetic Precursor of Gonadotropin-Releasing Hormone: A Multifunctional Prohormone

  • Karoly Nikolics
  • Peter H. Seeburg
Part of the Biochemical Endocrinology book series (BIOEND)


Mammalian reproduction is regulated by the pituitary hormones luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin. The secretion of these proteins from the anterior pituitary is controlled by humoral factors of the central nervous system (CNS) and by feedback signals in the form of hormonal factors from the gonads. LH stimulates ovulation and corpus luteum formation in females and androgen secretion in males. FSH stimulates the growth and maturation of ovarian follicles in females and spermatogenesis in males. Prolactin stimulates milk production and in certain species has direct gonadal effects.


Luteinizing Hormone Median Eminence Mammalian Reproduction GnRH Gene Corpus Luteum Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Karoly Nikolics
    • 1
  • Peter H. Seeburg
    • 1
  1. 1.Genentech, Inc.South San FranciscoUSA

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